Despite prophylactic peri-operative treatment with anti-emitics, many patients experience post-operative nausea and vomiting (PONV).
Evidence-based guidance for the treatment of PONV is needed.
Dopamine antagonists e.g. amisulpride (10 mg) and droperidol (1 to 1.25 mg) |
5-HT₃ antagonists e.g. ondansetron (4 mg) |
Histamine antagonists e.g. diphenhydramine (12.5 mg) |
Propofol (20 mg bolus) |
In case of failure of prophylaxis, medications from the prophylactic drug class should be excluded | Ondansetron is the drug of choice in patients who have not received prior prophylaxis |